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KMID : 0370019970110000025
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Chung-Ang Journal of Pharmacal Sciences
1997 Volume.11 No. 0 p.25 ~ p.31
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Anticancer Activity of Phenylpropanoid Isolated from Natural Product
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Abstract
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3.4´-dihydroxypropiophenone, a phenylpropanoid, purified from Betula platyphylla var, latifolia was evaluated on the antitumor activity. In vitro, the cytotoxicity was determined by 0.4% trypan blue dye exclusion method.
3.4´-dihydroxypropiophenone had the significant cytotoxicity to three tumor cell lines: human chronic myelogenous leukemia K-562, human promyelocytic leukemia HL-60, mouse leukemia P388. And the most sensitivity cell line was K-562(ED_50=5.12ug/ml).
The ED_50 of 3.4´-dihydroxypropiophenone against HL-60, P388 were 9.02 and 6.42 ug/ml respectively.
As a result, 3,4´-dihydroxypropiophenone was considered to show the antitumor activity.
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